姓 名：王栋
职称/职务：教授、博士生导师、执业药师
专 业：有机化学，药物化学
研究方向：含氮杂环的有机合成方法学，药物设计与合成
联系方式：vinigrol (微信号)
邮 箱：chem_wd@hotmail.com
办 公 室：yl8cc永利线路检测中心博达校区化学楼317房间
课题组网站：https://www.x-mol.com/groups/wang_dong
个人经历
学习经历：
2006 -2011 美国路易斯安那州立大学，有机化学专业，哲学博士
2003-2006 北京理工大学，应用化学专业，工学硕士
1999-2003 北京理工大学，化学工程与工艺专业，工学学士
工作经历：
2022.05–2025.01: yl8cc永利线路检测中心，药学院，副经理
2020.12–至今: yl8cc永利线路检测中心，yl8cc永利官网，教授
2014.12-2020.12: 天津科技大学，生物工程学院，副教授
2012.08-2014.12：天津长森药业有限公司，助理主任
2011.05-2012.08：天津药明康德新药开发有限公司，合成部组长
主讲课程
yl8cc永利官网是什么：《有机化学》，《零基础入门药学》《有机化学实验》, 《天然药物化学》,《药物合成反应》,《制药工程原理》，《有机合成路线设计》
研究生：《高等有机合成》《高等药物分析》
主持科研项目
1. 国家自然科学基金项目，22661053，在研，项目负责人。
2. 国家自然科学基金项目，22261051，在研，项目负责人。
3. 自治区天池英才-创新领军人才项目，结题，项目负责人。
4. 自治区杰出青年科学基金项目，2022D01E34，结题，项目负责人。
5. 自治区“天山创新团队计划”项目，2025D14005，在研，项目负责人。
6. 国家重点研发计划项目，2018YFA0901701，非细胞生物合成系统的构建与应用，结题，课题负责人。
7. 横向项目（山西集翔生物工程有限公司），结题，项目负责人。
8. 天津市应用基础及前沿技术研究计划项目，15JCYBJC53400，结题，项目负责人。
9. 天津市教委科研计划项目，2017KJ008，结题，项目负责人。
奖励情况：
2002年获得北京理工大学优秀员工奖；
2009年获得美国路易斯安那州立大学化学系优秀助研奖；
2010年获路易斯安那州立大学Coates会议奖；
2012年在药明康德新药开发有限公司晋升测试I中获得优秀成绩；
2013年获得天津经济技术开发区高级人才证书；
2014年获得萃智创新工程师称号；
2021年获得yl8cc永利线路检测中心青年教师教学竞赛优秀奖；
2022年获得Wiley出版社颁发的年度论文高下载次数奖；
2023年获得Wiley出版社颁发的年度论文高引用次数奖；
2025年获得第十五届发明创业奖人物奖；
2025年获得Wiley中国高贡献作者奖。
社会工作
Molecules期刊客座编辑（2025-）
研究生教育评估监测专家库专家（2022-）
新疆科技厅项目评审专家（2023-）
中国化学会会员（2018-）
美国化学会会员（2010-）
执业药师（2021-）
JOC, OL, Green Chem., Adv. Synth. Catal., OBC, TL, EJMC等期刊审稿人
代表性研究成果
以唯一第一作者或唯一通讯作者先后发表各类科研论文50篇左右，授权发明专利30余项。发表的主要学术论文有：
1. Dezhi Yang, Yunyun Liu, and Dong Wang*. Traceless Dearomatization-Enabled meta-C-H Alkylation and Alkenylation of Pyridines. Organic Chemistry Frontiers, 2026, 13 (x), xxxx-xxxx.
2. Fenlian Xu, Tong Han, Hua Xiao, Xinqiao Nie, Yiyan Hong and Dong Wang*. Cascade Migration-Aryloxylation of 2-Alkyl/Alkenyl Quinoline N-Oxides with Phenols: Practical Synthesis of 2,3-Disubstituted Quinolines. Organic Chemistry Frontiers, 2026, 13 (x), xxxx-xxxx.
3. Tong Han, Fenlian Xu, Xinqiao Nie and Dong Wang*. Direct C4–H amination of pyridines and quinolines under benign conditions. Organic & Biomolecular Chemistry, 2026, 24 (25), 5308-5317.
4. Xuemeng Wang, Liqing Xu, KeXin Ma, Yiyan Hong, Chuan Fu, Kai Tan*, and Dong Wang*. Redox-Neutral Assembly of Diheteroarylalkanes via Transient Directing Group Enabled C–H Methylenation. Organic Chemistry Frontiers, 2026, 13 (10), 3115-3122.
5. An Yan, Tong Han, Futian Mi, Turghun Muhammad and Dong Wang*. Solvent-Free Organocatalytic Synthesis of Fluorescent N-Alkylated Pyridones: A Metal/Base-Free Migration Strategy. Advanced Synthesis & Catalysis, 2026, 368 (7), e70335.
6. Hua Xiao, Reziyamu Wufuer, and Dong Wang*. Formal Synthesis of Ortho-Cyanated N-Heterocycles via Direct, Metal-Free Cyanation of N-Oxides Under Benign Conditions. Molecules, 2026, 31(2), 276.
7. Mingyue Zhou, Bolong Xu, Dong Wang, Zhaofeng Wu,* Lu Zhang,* and Sheng Cai. Wearable Acetone Gas Sensor Enabled by Quantum Dot-Sensitized Flower-like Ti3C2Tx for Metabolic Monitoring. ACS Sensors, 2026, 11, 157-167.
8. Liqing Xu, Xuemeng Wang, Yunyun Liu and Dong Wang*. Unlocking a Grignard Cascade: Three-Component Access to Complex Polycyclic Architectures from Quinolines. Organic Letters, 2025, 27 (49), 13475-13479.
9. Xu Wang, An Yan, Hua Xiao, Weiwei Xiao, Liqing Xu and Dong Wang*. C3-H Trifluoroacetylation of Quinolines and Pyridines: Access to Heteroaryl Ketones, Carboxylic Acids and Amides. Organic Letters, 2025, 27 (22), 5625-5631.
10. Danyi Liu, Fenlian Xu, Tong Han, Keyume Ablajan and Dong Wang*. Sustainable Synthesis of Heteroaryl Ethers from Azine N-Oxides via Phosphoramide Catalysis. Green Chemistry, 2025, 27 (26), 7788-7794. (Selected as Front Cover Paper)
11. Yuze Shi, Xuemeng Wang, Weiwei Xiao, Jiaxin Li and Dong Wang*. Development of Water-Soluble Nicotinamide Coenzyme Biomimetics for Improved Catalytic Efficiency. ChemistrySelect, 2025, 10 (x), DOI: 10.1002/slct.202501957.
12. Liqing Xu, Xu Wang, Dezhi Yang, Xiaolong Yang and Dong Wang*. Direct C3-H Alkylation and Alkenylation of Quinolines with Enones. Angewandte Chemie International Edition, 2025, 64 (1), e202416451.
13. Lu Zhang,* Ao Li, Mingping Shen, Zhiwei Zhang, Reziyamu Wufuer and Dong Wang*. Palladium–platinum bimetallic modified MXene nanozyme for highly sensitive detection of active substances with acetylcholinesterase inhibitory effect. Talanta, 2025, 282, 127020.
14. Kaijuan Wang, Chengcheng Gong, Weiwei Xiao, Ablimit Abdukader and Dong Wang*. Accessing 1,8-Naphthyridone-3-Carboxylic Acid Derivatives and Application to the Synthesis of Amfonelic Acid. Journal of Organic Chemistry, 2024, 89 (8), 5811-5824.
15. Changna Bu, Kaijuan Wang, Chengcheng Gong and Dong Wang*. Green and Fast 2-Aryloxylation/Amination of Quinolines. Green Chemistry, 2024, 26 (8), 4659 - 4664.
16. Xiaolong Yang, Danyi Liu and Dong Wang*. Accessing Tetrahydroquinaldic Amide and Homoproline Derivatives by Dearomative Difunctionalization of Heteroaromatics. Asian Journal of Organic Chemistry, 2024, 13(1), e202300559.
17. Qian Ma, Yuze Shi and Dong Wang*. Phosphonium Salt-Promoted C2–H Functionalization of Heterocyclic N-Oxides. Organic Letters, 2023, 25(51), 9181-9185.
18. 王凯娟，许利清，王栋。吡啶及喹啉氮氧化物C2-H键官能团化反应的最新进展，中国科学：化学，2023, 53 (8), 1369-1376.
19. Dong Wang*, Liqing Xu,Shixin Zheng and Xiaolong Yang. Transition-Metal-Free Regioselective Direct C2, C4 Difunctionalization and C2, C4, C6 Trifunctionalization of Pyridines. Advanced Synthesis & Catalysis, 2022, 364 (16), 2720-2728.
20. Shixin Zheng, Dong Wang*, Mindong Huang and Peng Yu*. Rapid Generation of Tetrahydropyridines and Tetrahydroquinolines by Dearomative Cyanation/Grignard Addition. Chemistry-An Asian Journal, 2022, 17, e202200077.
21. Dong Wang*, Laurent Désaubry, Gaoyu Li, Mindong Huang and Shixin Zheng. Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N-oxide Chemistry. Advanced Synthesis & Catalysis, 2021, 363 (1), 2-39.
22. Dong Wang, Redouane Tabti, Sabria Elderwish, Amel Djehal, Nora Chouhad, Franck Pinot, Peng Yu, Canan G. Nebigil, Laurent Désaubry. SFPH proteins as therapeutic targets for a myriad of diseases. Bioorganic & Medicinal Chemistry Letters, 2020, 30 (22), 127600.
23. Xin Jin, Jianling Xie, Michael Zabolocki, Xuemin Wang, Tao Jiang, Dong Wang, Laurent Désaubry, Cedric Bardy, Christopher G Proud. The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis. Journal of Biological Chemistry, 2020, 295(29), 9855-9867.
24. Tian Zhao, Yujie Liu, Yanfei Hao, Wei Zhang, Li Tao, Dong Wang, Yuyin Li, Zhenxing Liu, Edward A McKenzie, Qing Zhao*, Aipo Diao*. Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Investigational New Drugs, 2020, doi: 10.1007/s10637-020-01011-3, in press.
25. Dong Wang*, Mindong Huang, Gaoyu Li, Shixin Zheng, Peng Yu. Scalable Synthesis of a Tetrasubstituted 7-Azabenzofuran as a Key Intermediate for a Class of Potent HCV NS5B Inhibitors. Tetrahedron, 2020, 76 (48), 131642.
26. Linru Dong, Xinyue Ma, Yu Fan, Dong Wang*. A One‐Pot Dearomative Approach to C4‐Alkylated Tetrahydropyridines and Tetrahydroquinolines. Asian Journal of Organic Chemistry, 2020, 9(10), 1571-1575.
27. Lianbo Zhao, Lei Hao, Yupeng Fu, Yan Cheng, Guojun Pan, Laurent Désaubry, Peng Yu*, Dong Wang*. Accessing 1,8-Naphthyridones by Metal-Free Regioselective Amination of Pyridine N-oxides/Acid-Mediated Cyclization. Advanced Synthesis & Catalysis, 2020, 362, 3841-3845.
28. Dong Wang*, Yu Fan, Peng Yu and Laurent Désaubry*. Recent advances in the synthesis of 2,3-dihydropyrroles. Chemical Communications, 2020, 56, 5584-5592.
29. Chunsheng Fu, Gaoyu Li, Meng Shen, Longxia Zhang, Peng Yu and Dong Wang*. Facile and Efficient Synthesis of Tri- and Tetrasubstituted 7-Azabenzofuran Derivatives. Asian Journal of Organic Chemistry, 2020, 9(5), 749-752.
30. Dong Wang*, Yuanyang Jiang, Linru Dong, Gaoyu Li, Baoying Sun, Laurent Désaubry and Peng Yu. One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines. Journal of Organic Chemistry, 2020, 85(7), 5027-5037. (Selected as Front Cover Paper)
31. Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil and Laurent Désaubry*. Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases. Cellular and Molecular Life Sciences, 2020, 77, 3525-3546.
32. Dong Wang*, Xinyue Ma, Linru Dong, Hairong Feng, Peng Yu and Laurent Désaubry*. Stereoselective four-component synthesis of functionalized 2,3-dihydro-4-nitropyrroles. Frontiers in Chemistry, 2019, 7:810, doi: 10.3389/fchem.2019.00810.）
33. Dong Wang*, Zhentao Wang, Zhenlin Liu, Mindong Huang, Jianyong Hu, and Peng Yu*. Strategic C-C bond-forming dearomatization of pyridines and quinolines. Organic Letters, 2019, 21(12), 4459-4463.
34. Dong Wang*, Zhenlin Liu, Zhentao Wang, Xinyue Ma, and Peng Yu*. Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides. Green Chemistry, 2019, 21 (1), 157-163.
35. Amel Djehal, Mohammad Krayem, Ahmad Najem, Hassan Hammoud, Thierry Cresteil, Cannon Nebigil, Dong Wang, Peng Yu, Embak Bentouhami, Ghanem Ghanem, Laurent Désaubry*. Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells. European Journal of Medicinal Chemistry, 2018, 155, 880-888.
36. Dong Wang, Linna Li, Hairong Feng, Hua Sun, Fabrice Almeida-Veloso, Marine Charavin, Peng Yu, Laurent Désaubry*. Catalyst-free three component synthesis of highly functionalized 2,3-dihydropyrroles. Green Chemistry, 2018, 20 (12), 2775-2780.
37. Dong Wang*, Jianyong Hu, Junjie Zhao, Meng Shen, Yuxi Wang, and Peng Yu*. Transition-metal-free access to 7-azaindoles. Tetrahedron, 2018, 74 (30), 4100-4110.
38. Dong Wang*, Meng Shen, Yuxi Wang, Jianyong Hu, Junjie Zhao, and Peng Yu*. Access to Furo[2,3-b]pyridines by Transition-Metal-Free Intramolecular Cyclization of C3-substituted Pyridine N-oxides. Asian Journal of Organic Chemistry, 2018, 7(5), 879-882.
39. Dong Wang*, Hairong Feng, Linna Li, Zhenlin Liu, Zhongli Yang, and Peng Yu*. Access to 8-Azachromones via Activation of C-H in N-Oxides. Journal of Organic Chemistry, 2017, 82(20), 11275-11287.
40. Dong Wang*, Yuxi Wang, Junjie Zhao, Meng Shen, Jianyong Hu, Zhenlin Liu, Linna Li, Furen Xue, and Peng Yu*. Strategic Approach to 8-Azacoumarins. Organic Letters, 2017, 19(5), 984-987.
41. Dong Wang*, Longfei Miao, Lixia Feng, Qingwei Yao, Gnel Mkrtchyan, William E. Crowe, Evgueni E. Nesterov, Yuekui Wang, Xiaoting Zhang and Peng Yu*. Mechanism and origin of stereoselectivity in Robinson annulations leading to bicyclo[3.3.1]nonanes: a rare Curtin–Hammet scenario. Journal of Physical Organic Chemistry, 2017, 30: e3595. DOI: 10.1002/poc.3595.
42. Dong Wang*, Junjie Zhao, Yuxi Wang, Jianyong Hu, Linna Li, Longfei Miao, Hairong Feng, Laurent Désaubry, and Peng Yu*. A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N-Oxides. Asian Journal of Organic Chemistry, 2016, 5(12), 1442-1446. (Selected as Front Cover Paper)
43. Hua Sun, Yazhou Zhang, Weina Ding, Xue Zhao, Xiaotong Song, Dong Wang, Yashan Li, Kailin Han, Yang Yang, Ying Ma, Runling Wang, Dong Wang*, Peng Yu*. Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry, 2016, 123(10), 365–378.
44. Dong Wang*, Yuxi Wang, Junjie Zhao, Linna Li, Longfei Miao, Dong Wang, Hua Sun and Peng Yu*. A Highly Practical and Convenient Halogenation of Fused Heterocyclic N-oxides. Tetrahedron, 2016, 72(38), 5762-5768.
45. Dong Wang*, William E. Crowe. A facile approach to tricyclo[6.4.0.04,9]-dodecane framework. Chinese Chemical Letters, 2015, 26(2), 238-242.
46. Dong Wang*, Hailing Jia, Wuchang Wang and Zhe Wang. A practical and mild chlorination of fused heterocyclic N-oxides. Tetrahedron Letters, 2014, 55(51), 7130-7132.
47. Dong Wang and William E. Crowe*. One-Carbon Bridge Stereocontrol in Robinson Annulations Leading to Bicyclo[3.3.1]nonanes. Organic Letters, 2010, 12(6), 1232-1235.
48. Dong Wang, William E. Crowe*, Robert M. Strongin and Martha Sibrian-Vazquez. Exploring the pH dependence of viologen reduction by α-carbon radicals derived from Hcy and Cys. Chemical Communications, 2009, 14, 1876-1878.
已授权专利：
1. 王栋，刘淡宜，徐粉莲，韩通。一种含氮杂环氮邻位取代的芳基醚的合成方法。中国专利，申请日：2025年2月24日，申请号：2025101991955；已授权，授权日：2025年11月28日。
2. 王栋，王喆，浩日沁巴图。黄藤素及其类似物的制备方法。中国专利，2014，公开号：CN 103980271A.
3. 王栋，郁彭，滕玉鸥，王玉玺，赵俊杰，沈蒙，胡健湧，刘振林，张倩，袁媛，陈文竹。一种8-氮杂香豆素的合成方法及其在抗肿瘤药物中的应用。中国专利，2019/03，已授权。公开号：CN106810560A。专利号：ZL201611202287.1。
4. 王栋，郁彭，德奥希里•洛朗, 李林娜，孙华。新型五取代2,3-二氢吡咯衍生物及其制备方法和应用。中国专利，2017/10，已授权。公开号：CN107721895A。授权日：2020/03/20, 专利号：ZL201710952997.4。
5. 王栋，郁彭，胡健湧，马欣悦。一种哮喘药物Fevipiprant的简洁合成方法。中国专利，2018/02，已授权。专利号：ZL201810161042.1。
6. 王栋，郁彭，刘振林，王振涛。2-吡啶甲基硫醚的合成方法及相关药物的合成工艺。中国专利，2018/09, 已授权。专利号：ZL201811091737.3。
7. 王栋，李高宇，郑世鑫，崔姗姗，丁颖，崔丽，滕玉鸥，郁彭。一类7-氮杂苯并呋喃衍生物及其在抗肿瘤药物中的应用。中国专利，2020/10, 已授权。专利号：202011100856.8。
8. 王栋，姜远洋，董琳茹，崔珊珊，丁颖，崔丽，滕玉鸥，郁彭。一种1,4-二氢喹啉以及1,4-二氢吡啶类化合物的合成方法及其在抗肿瘤药物中的应用。中国专利，2020/01，已授权。专利号：ZL202010020581.0。
9. 郁彭，王栋，滕玉鸥，苗龙飞，王静，张倩，袁媛。一种新型水溶性靛红衍生物及其制备方法与应用。中国专利，2016/07，已授权，专利号：ZL201610589432.X。世界专利，2018/01，公开号：WO2018014368A1。美国专利，公开号：US 20190359568A1, 专利号：10703717。2019/11/28公开, 2020/03/04授权。
10. 郁彭，王栋，刘振林，赵俊杰，李林娜，冯海荣。一种8-氮杂色酮的合成方法。中国专利，2017/07，已授权。专利号：201710595269.2。
